{"id":25735,"date":"2025-12-23T17:46:50","date_gmt":"2025-12-23T16:46:50","guid":{"rendered":"https:\/\/lluita.org\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\/"},"modified":"2025-12-23T18:05:13","modified_gmt":"2025-12-23T17:05:13","slug":"investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi","status":"publish","type":"post","link":"https:\/\/lluita.org\/en\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\/","title":{"rendered":"Researchers from the Foundation take part in a pioneering study evaluating a new therapeutic option for legionellosis"},"content":{"rendered":"

Researchers from the Foundation for the Fight against Infections and the Germans Trias i Pujol Research Institute<\/a> (IGTP), including Dr Llu\u00efsa Pedro-Botet<\/strong>, head of the Severe Bacterial Infections<\/a> line and co-head of the Infections in Immunocompromised People line at the Foundation<\/a>, have published a groundbreaking study<\/a> in the International Journal of Infectious Diseases<\/em><\/strong> on the activity of delafloxacin. This is a new antibiotic targeting bacteria of the Legionella<\/em> genus inside cells. The study was sponsored by Menarini<\/a> Italy.<\/p>\n

\n

This research also involved Drs Nieves Sopena, Esteban Reynaga and Javier D\u00edez de los R\u00edos<\/strong>, members of the Foundation for the Fight against Infections and the Germans Trias i Pujol Hospital. Furthermore, the experiments were carried out at IGTP by Roger Cortes, under the direction and supervision of Dr Noem\u00ed Parraga, with the participation of Elisenda Arqu\u00e9.<\/p>\n

Legionellosis: a growing public health challenge<\/strong><\/h3>\n

Legionellosis remains a public health problem in Europe, with an increasing incidence in recent years. In fact, in Spain, almost 2,000 cases were recorded in 2022, representing a 43% rise compared to the previous year.<\/strong><\/p>\n

The usual treatment is based on antibiotics such as levofloxacin, but the search for new alternatives is crucial given the rise in cases,<\/strong> the growing number of side effects and the potential emergence of resistance.<\/p>\n

Key findings: greater efficacy and improved safety<\/strong><\/h3>\n

The study, entitled \u201cIn vitro characterization of delafloxacin activity against intracellular Legionella: Exploring new treatment options for Legionnaires\u2019 disease\u201d<\/em><\/strong>, compared for the first time the efficacy of delafloxacin with levofloxacin in a cellular model of Legionella<\/em> infection.<\/p>\n

The results show that delafloxacin reduces the intracellular multiplication capacity of the bacterium between 5 and 10 times<\/strong> more than levofloxacin, with a minimum effective concentration (MIEC90) of 0.005 mg\/l for most species and strains analysed, compared to 0.025 mg\/l for levofloxacin. Moreover, considering the results of several pivotal clinical studies, delafloxacin demonstrates a superior safety profile.<\/strong><\/p>\n

These findings suggest that delafloxacin could become a more effective and safer therapeutic alternative for the treatment of legionellosis,<\/strong> although confirmation through clinical studies in real patients will be necessary. The involvement of researchers from the Foundation for the Fight against Infections in this work reinforces the institution\u2019s commitment to translational research and improving the treatment of severe bacterial infections..<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Researchers from the Foundation for the Fight against Infections and the Germans Trias i Pujol Research Institute (IGTP), including Dr Llu\u00efsa Pedro-Botet, head of the Severe Bacterial Infections line and co-head of the Infections in Immunocompromised People line at the Foundation, have published a groundbreaking study in the International Journal of Infectious Diseases on the […]<\/p>\n","protected":false},"author":8,"featured_media":25732,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[276],"class_list":["post-25735","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-serious-bacterial-infections"],"acf":[],"yoast_head":"\nResearchers from the Foundation take part in a pioneering study evaluating a new therapeutic option for legionellosis - Fundaci\u00f3 Lluita contra les Infeccions<\/title>\n<meta name=\"description\" content=\"Discover what legionellosis is, how it spreads and the key prevention measures to avoid this disease caused by Legionella.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lluita.org\/en\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers from the Foundation take part in a pioneering study evaluating a new therapeutic option for legionellosis\" \/>\n<meta property=\"og:description\" content=\"Discover what legionellosis is, how it spreads and the key prevention measures to avoid this disease caused by Legionella.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lluita.org\/en\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\/\" \/>\n<meta property=\"og:site_name\" content=\"Fundaci\u00f3 Lluita contra les Infeccions\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-23T16:46:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-23T17:05:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lluita.org\/custom\/uploads\/2025\/12\/Lluita_30oct2025-184-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"LLUITA Admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"LLUITA Admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/lluita.org\\\/en\\\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/lluita.org\\\/en\\\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\\\/\"},\"author\":{\"name\":\"LLUITA Admin\",\"@id\":\"https:\\\/\\\/lluita.org\\\/#\\\/schema\\\/person\\\/ebbfd4b21b6e55289e039158312b195a\"},\"headline\":\"Researchers from the Foundation take part in a pioneering study evaluating a new therapeutic option for legionellosis\",\"datePublished\":\"2025-12-23T16:46:50+00:00\",\"dateModified\":\"2025-12-23T17:05:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/lluita.org\\\/en\\\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\\\/\"},\"wordCount\":388,\"image\":{\"@id\":\"https:\\\/\\\/lluita.org\\\/en\\\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/lluita.org\\\/custom\\\/uploads\\\/2025\\\/12\\\/Lluita_30oct2025-184-scaled.jpg\",\"articleSection\":[\"Serious bacterial infections\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/lluita.org\\\/en\\\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\\\/\",\"url\":\"https:\\\/\\\/lluita.org\\\/en\\\/investigadors-de-la-fundacio-participen-en-un-nou-estudi-que-avalua-una-nova-opcio-terapeutica-per-a-la-legionel%c2%b7losi\\\/\",\"name\":\"Researchers from the Foundation take part in a pioneering study evaluating a new therapeutic option for legionellosis - 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